Gynecologic oncologyHumansAnimalsFemalePoly(ADP-ribose) Polymerase InhibitorsPoly (ADP-Ribose) Polymerase-1
G-M6, an oleanane triterpenoid, represents a novel scaffold for PARP1 inhibition and anticancer activity.
Meng Ding, Xu Li, Hongling Wang, Xiaoqing Jia, Wenbin Gao
Published: 202610.1016/j.ygyno.2025.10.035
Abstract
BACKGROUND: The inhibition of Poly (ADP-ribose) polymerase 1 (PARP1) is a clinically validated strategy for treating cancers with homologous recombination (HR) deficiencies. Herein, we report the discovery and characterization of G-M6, a ginsenoside…
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