Experimental cell researchHumansDrug ResistanceNeoplasmColorectal NeoplasmsFluorouracil
Tumor cell exosome circ-0023919 promotes EMT through the miR-197-5p/ICAM5 axis and enhances the drug resistance of colorectal cancer to 5-fu.
Jingjing Zhang, Yuanxiang Wu, Yaping Wang, Huihui Zeng
Published: 202610.1016/j.yexcr.2025.114866
Abstract
5-Fluorouracil (5-Fu) is a cornerstone chemotherapeutic agent in the treatment of colorectal cancer (CRC). However, its clinical efficacy is frequently hampered by the development of drug resistance, which remains a major obstacle to successful treat…
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