Experimental cell researchAnimalsGlycolysisHypertensionPulmonaryMice
Glycolysis inhibition and AMPK activation: a critical role of CTRP1 deficiency in the treatment of hypoxia-induced pulmonary hypertension.
Yu Zhang, Weiqiang Chen, Kai Yang, Tao Hao, Wenfeng Cao, Shuqiang Dong
Published: 202610.1016/j.yexcr.2025.114838
Abstract
In pulmonary hypertension (PH), metabolic enhancement of glycolysis drives a hyperproliferative and apoptosis-resistant phenotype in pulmonary artery smooth muscle cells (PASMCs), which is a key pathological process leading to pulmonary vascular remo…
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