Experimental cell researchDictyosteliumCalciumAutophagyCalcium ChannelsCalcium Signaling
Elucidating the impact of trans-ned-19 on two-Pore channel 2 mutants of Dictyostelium: changes in intracellular calcium levels and subsequent effect on autophagic flux.
Ashima Thakur, Shweta Saran
Published: 202610.1016/j.yexcr.2025.114829
Abstract
Two-Pore Channel 2 (TPC2) are calcium (Ca2+) release channels regulated by Nicotinic Acid Adenine Dinucleotide Phosphate (NAADP), primarily localized to the endolysosomal system. TPC2 regulates diverse Ca2+-dependent processes such as cell proliferat…
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