Experimental cell researchAnimalsMetforminWnt Signaling PathwayOssificationHeterotopic
Metformin inhibits heterotopic ossification of mouse Achilles tendon by inhibiting the Nr4a1/Wnt/β-catenin signaling pathway.
Danxia Zheng, Mengyu Jiang, Wenjie Wang, Jianglin Yu, Xiaoyang Qi, Yixin Chen
Published: 202610.1016/j.yexcr.2025.114824
Abstract
Heterotopic ossification is a pathological process characterized by aberrant bone formation in soft tissues, leading to joint pain, stiffness, functional impairment, and poor quality of life. We used a mouse Achilles tendon heterotopic ossification m…
Preview only. Read the full abstract at the source