Experimental cell researchHumansPrecursor T-Cell Lymphoblastic Leukemia-LymphomaAnimalsCell ProliferationMice
The BET degrader BETd-246 demonstrated significant anti-tumor efficacy in T-cell acute lymphoblastic leukemia by inhibiting TRAT1.
Haixia Ge, Huike Bai, Juanjuan Yu, Jia Cheng, Zhongqin Jin, Jian Pan, Xue Li, Chunxia Shi, Yang Yang, Shaoyan Hu, Yanfang Tao
Published: 202510.1016/j.yexcr.2025.114791
Abstract
T cell acute lymphoblastic leukemia (T-ALL) is a rare lymphoblastic leukemia characterized by T lymphocyte heterogeneity and diverse genetic abnormalities, accounting for approximately 15 % of childhood leukemias. BETd-246 serves as a tethering agent…
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