The dual function model revisited by thyroid hormone receptor knockouts: Unliganded state controlling the initiation of adult organ development while liganded state ensuring larval tissue resorption during metamorphosis.

Thyroid hormone (T3) plays a critical role in vertebrate development, particularly in postembryonic organ remodeling and maturation. Plasma level of T3 peaks during postembryonic development, which corresponds to the neonatal period in mammals when m…

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