Journal of pharmaceutical sciences
Do we worry too much about polysorbate degradation? An industry-wide perspective with real-life case studies.
Klaus Wuchner, Felix Nikels, Patrick Garidel, Karoline Bechtold-Peters, Sanjay Gupta, Pierre Guibal, Linda Yi, Neil Steinmeyer, Cyrille Chery, Sebastian Peuker, Ryan E Mould, Shousong Jason Zhang, Charlie Bupp, Felix Wiggers, Yogita Krishnamachari
Published: 202610.1016/j.xphs.2026.104169
Abstract
Polysorbates are commonly used in biotherapeutic drug formulations, but their stability over the course of the product's shelf life is a matter of concern. An industry-wide survey involving 15 biopharmaceutical companies found that 23 biotherapeutic…
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