Journal of pharmaceutical sciences
Challenges in surfactant removal from biopharmaceutical formulations using tangential flow filtration (TFF) and spin columns.
Kristian Le Vay, Benjamin Steinborn, Constanze Helbig, Andrea Arsiccio, Maksymilian M Zegota, Christa von der Schulenburg, Angelika Reichel, Tim Menzen, Andrea Hawe
Published: 202510.1016/j.xphs.2025.104141
Abstract
Surfactants such as polysorbate 20 (PS20), polysorbate 80 (PS80), and poloxamer 188 (P188) are integral to the stabilization of protein therapeutics, yet their removal is often required during formulation development and analytical characterization.…
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