Journal of pharmaceutical sciences
Lipid-free, thermostable mRNA vaccines prepared using atomic layer deposition.
Holly J Coleman, Amber Rauch, Erika Langsfeld, Kimberly Anderson, Urvi Parlikar, Hans H Funke, Robert L Garcea, Theodore W Randolph
Published: 202510.1016/j.xphs.2025.104066
Abstract
Lipid nanoparticle (LNP) formulations of mRNA vaccines have played a pivotal role in combatting SARS-CoV-2 infections and are expected to be a useful vaccine modality against other pathogens. However, the instability of mRNA-LNP vaccines requires the…
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