Journal of pharmaceutical sciencesAdministrationIntranasalGenisteinBiological AvailabilityAnimals
Genistein-loaded nanostructured lipid carriers for intranasal brain delivery: Preparation, optimization, in-vitro evaluation, and amelioration of bioavailability.
Nabil K Alruwaili, Ameeduzzafar Zafar, Omar Awad Alsaidan, Mohd Yasir, Lubhan Singh, Mohammad Khalid, Md Ali Mujtaba, Dibya Sundar Panda
Published: 202510.1016/j.xphs.2025.104025
Abstract
Genistein (GN) is a natural isoflavonoid phytoestrogen found in soybeans. It has various drawbacks, like poor solubility, high metabolism, and low oral bioavailability. This research work aimed to develop GN-loaded nanostructured lipid carriers (NLCs…
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