HGG advances
Application of the STAAR Framework in Detecting Rare Variant Associations with Alzheimer's Disease and Related Dementias: Insights and Implications.
Dongyu Wang, Sabrina Abbruzzese, Nancy Heard-Costa, Andy Rampersaud, Eden Martin, Adam Naj, Bilcag Akgun, Brian Kunkle, Sudha Seshadri, Gina Peloso, Alzheimer's Disease Neuroimaging Initiative, Alzheimer’s Disease Sequencing Project, Anita L DeStefano, Zilin Li, Xihao Li
Published: 202610.1016/j.xhgg.2026.100574
Abstract
Rare genetic variation is considered a potential source of heritability in individuals with sporadic Alzheimer's Disease and related dementias (ADRD). The STAAR framework leverages multiple functional annotations of genetic variants and combines asso…
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