Cell genomics
Leveraging ancestral recombination graphs for scalable mixed-model analysis of complex traits.
Jiazheng Zhu, Georgios Kalantzis, Ali Pazokitoroudi, Árni Freyr Gunnarsson, Hrushikesh Loya, Han Chen, Sriram Sankararaman, Pier Francesco Palamara
Published: 202510.1016/j.xgen.2025.101072
Abstract
Recent algorithmic advances have enabled the inference of genome-wide ancestral recombination graphs (ARGs) from large genomic cohorts, providing detailed models of genealogical relatedness along the genome. These inferred ARGs can complement genotyp…
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