Cell genomicsHumansAllelesGene FrequencyGenesImmunoglobulin Heavy Chain
The human IG heavy chain constant gene locus is enriched for large structural variants and coding polymorphisms that vary among human populations.
Uddalok Jana, Oscar L Rodriguez, William Lees, Eric Engelbrecht, Zach Vanwinkle, Ayelet Peres, William S Gibson, Kaitlyn Shields, Steven Schultze, Abdullah Dorgham, Matthew Emery, Gintaras Deikus, Robert Sebra, Evan E Eichler, Gur Yaari
Published: 202610.1016/j.xgen.2025.101058
Abstract
The human immunoglobulin heavy chain constant (IGHC) domain of antibodies (Abs) is responsible for effector functions critical to immunity. This domain is encoded by genes in the IGHC locus, where descriptions of genomic diversity remain incomplete.…
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