Cell reports. MedicinePericytesAnimalsHumansBasic Helix-Loop-Helix ProteinsMice
Targeting TCF21-TCF3 heterodimer in tumor-associated pericytes attenuates hematogenous metastasis by restoring pericyte gatekeeper function.
Wenqian Yin, Haiqin Yao, Xiaobo Li, Wenxuan Pan, Yikan Zhang, Chenran Wang, Lijuan Deng, Changwei Lin, Zhi-Min Zhang, Jinghua Pan, Shuai Han, Zhongshun Tang, Zhan Zhao, Chengjun Zhu, Shitao Li
Published: 202610.1016/j.xcrm.2025.102569
Abstract
Hematogenous metastasis is the leading cause of cancer mortality, with dysfunction of pericytes, key components of tumor vessels, playing a central role in facilitating metastatic spread. Although anti-pericyte therapies are gaining recognition for t…
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