Cell reports. MedicineAnimalsInterleukin-15BrainSignal TransductionInflammation
Anti-IL-15 treatment reduces acute lentivirus inflammation and signaling in the brain.
Daniel R Ram, Raja Mohan Gopalakrishnan, Malika Aid, Kyle Kroll, Jasmine Miftahof, Omar Aristizabal, Eunice Kayitare Gikundiro, Caitlin Davis, Marco M Hefti, Kimberly L Fiock, Brook Tilahun, Yvette Umutoniwase, Kate Loidolt, Christine M Fennessey, Noe B Mercado
Published: 202610.1016/j.xcrm.2025.102567
Abstract
HIV-associated neurocognitive disorder (HAND) remains a significant complication in people living with HIV, with inflammation playing a central role in its pathogenesis. Understanding how the brain's immune network responds to lentiviral infection is…
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