Cell reports. MedicineHumansLeukemiaMyeloidAcuteTumor Protein p73
ΔNp73 isoform defines a TP53-mutant-like poor-risk subgroup of acute myeloid leukemia.
Diego A Pereira-Martins, Cesar Ortiz, Isabel Weinhäuser, Albertus T J Wierenga, Vincent van den Boom, Fatemeh Mojallali, Dominique Sternadt, Nisha K van der Meer, Shanna M Hogeling, Thiago M Bianco, Prodromos Chatzikyriakou, Douglas R Silveira, Emanuele Ammatuna, Antonio R Lucena-Araujo, Lynn Quek
Published: 202610.1016/j.xcrm.2025.102540
Abstract
Among acute myeloid leukemia (AML) patients, a subgroup remains notoriously refractory to current treatment options, with underlying mechanisms poorly understood. Here, using a multi-omics approach, we reveal that this resistant patient subgroup is c…
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