Cell reports. MedicinePyroptosisMelanomaHumansProto-Oncogene Proteins B-rafHistones
5-HT reuptake blockade induces pyroptosis in BRAFV600E-mutated melanomas via remodeling histone serotonylation.
Aicun Li, Shoujia Xu, Jiachen Fan, Jingwei Liu, Xiaoyu Song, Liu Cao, Zhicheng Gong, Xiao Lu
Published: 202610.1016/j.xcrm.2025.102537
Abstract
The dual challenges of limited therapeutic options due to de novo or acquired resistance and psychological distress in patients with melanoma necessitate innovative treatment strategies. Here, we identify paroxetine hydrochloride (PH), a Food and Dru…
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