Veterinary microbiologyAnimalsPorcine respiratory and reproductive syndrome virusSwineApoptosisThymus Gland
NSP9 is a key virulence determinant in highly pathogenic PRRSV-mediated thymic injury via synergistic activation of apoptotic and metabolic pathways.
Fanliang Meng, Chenchen Cui, Xinyi Huang, Qianru Zhang, Longshuai Yao, Xuehui Cai, Tongqing An, Gang Wang
Published: 202610.1016/j.vetmic.2025.110868
Abstract
Highly pathogenic porcine reproductive and respiratory syndrome virus (HP-PRRSV) induces severe thymic atrophy, contributing to immunosuppression in infected piglets. This study investigated the roles of viral nonstructural proteins NSP9 and NSP10 in…
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