Veterinary microbiologyAnimalsCD4-Positive T-LymphocytesProgrammed Cell Death 1 ReceptorMiceLymphopenia
Vitamin C combined with anti-PD-1 antibody alleviates peripheral lymphopenia and enhances CD4+ T-cell antiviral immunity during BVDV infection.
Yang Li, Yue Liang, Linru He, Peilong Li, Ruosi Chen, Shuang Wang, Pengyu Zhang, Bin Xu, Yulong Zhou, Zhanbo Zhu, Jianjun Zhao, Yu Liu
Published: 202610.1016/j.vetmic.2025.110825
Abstract
Bovine viral diarrhea virus (BVDV)-induced lymphopenia is associated with immune dysfunction. Vitamin C (VC) improves immune response by increasing peripheral blood lymphocyte (PBL) count, thereby promoting T-cell activation and release of IL-2 and I…
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