Veterinary microbiologyFoot-and-Mouth Disease VirusAnimalsCapsid ProteinsSerogroupAntibodies
Two residue mutations in VP1 of FMDV serotype A cause significant antigenic variation via reorientation of G-H loop revealed by lineage-specific neutralizing antibodies from the natural hosts.
Shulun Huang, Jiaxin Yang, Fengjuan Li, Hehe Zhang, Yimei Cao, Jingjing Zha, Huifang Bao, Pinghua Li, Linfeng Liang, Zaixin Liu, Kun Li, Zengjun Lu, Jinlian Hua, Qiang Zhang
Published: 202510.1016/j.vetmic.2025.110748
Abstract
Foot-and-mouth disease virus (FMDV) serotype A exhibits extensive genetic and antigenic diversity, complicating vaccine strain selection. Here, we identified two distinct panels of host-derived neutralizing antibodies (nAbs) specific to the SEA97 lin…
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