Veterinary immunology and immunopathologyAnimalsSorafenibDogsMyeloid-Derived Suppressor CellsCarcinoma
Sorafenib inhibits myeloid-derived suppressor cell infiltration in canine transitional cell carcinoma.
Shohei Yokota, Wataru Fujii, Tomoki Motegi, Mao Komori, Reo Nishi, James K Chambers, Kazuyuki Uchida, Tomohiro Yonezawa, Yasuyuki Momoi, Shingo Maeda
Published: 202510.1016/j.vetimm.2025.111019
Abstract
Myeloid-derived suppressor cells (MDSCs)-immature cells with immunosuppressive properties-are promising therapeutic targets for cancer immunotherapy. However, established therapies targeting MDSCs remain lacking, and novel molecules are needed to reg…
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