VaccineLeptospiraWhole Genome SequencingMultilocus Sequence TypingBacterial VaccinesQuality Control
Whole-genome sequencing as a regulatory tool for quality control of Leptospira strains for vaccines and diagnostics.
Natasha Rodrigues de Oliveira, Mara Andrade Colares Maia, Frederico Schmitt Kremer, Anael da Luz Moreira, Beatriz Campos da Motta Santos, Gabriel San Martins Kunde, Alexandra Lehmkuhl Gerber, Ana Tereza Ribeiro Vasconcelos, Mariana Antão Cavalcanti Pizani, Paulina Consuelo Morales Arancibia, Thaís Larré Oliveira Bohn, Odir Antônio Dellagostin
Published: 202610.1016/j.vaccine.2025.128110
Abstract
The maintenance of well-characterized Leptospira seed strains is critical for vaccine production and diagnostic applications. Conventional methods such as the cross-agglutinin absorption test (CAAT), multilocus variable-number tandem repeat analysis…
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