VaccineAnimalsCD8-Positive T-LymphocytesDendritic CellsLiposomesMice
Intraperitoneal administration of cationic liposomes containing a TLR3 agonist recruits type I conventional dendritic cells and primes a local CD8+ T cell response.
Signe Tandrup Schmidt, Julie Zimmermann, Katharina Wørzner, Yvonne Perrie, Thomas Lindenstrøm, Rasmus Mortensen, Dennis Christensen, Gabriel Kristian Pedersen
Published: 202610.1016/j.vaccine.2025.128029
Abstract
BACKGROUND: Therapeutic vaccines capable of eliciting CD8 T cell responses are a promising approach in cancer, but the magnitude of immune responses to peptide-based vaccine technologies has so far been modest in humans. The cationic liposome adjuvan…
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