VaccineAnimalsAdministrationIntranasalInfluenza VaccinesMice
Enhancing vaccine immunogenicity through heterologous prime-boost regimen with multiple nasal boosting with liposomal TLR7 ligand.
Tomoko Hayashi, Shiyin Yao, Fumi Sato-Kaneko, Renna Cozza, Hiroyuki Baba, Jasmine Jin, Ian Mclaughlin, Fernando Gil, Paola Anguiano Quiroz, Nikunj M Shukla, Michael Chan, Howard B Cottam, Dennis A Carson
Published: 202510.1016/j.vaccine.2025.127778
Abstract
OBJECTIVES: Despite the clinical efficacy of current intramuscular influenza vaccines in reducing the severity of seasonal infection, they exhibit limited induction of mucosal immunity, which is essential for preventing viral transmission. In additio…
Preview only. Read the full abstract at the source