Translational research : the journal of laboratory and clinical medicinePulmonary DiseaseChronic ObstructiveAnimalsCellular SenescenceNeutrophils
Neutrophil-derived exosomal thrombospondin-1 exacerbates endothelial progenitor cell senescence and lung injury via TGF-β/SMAD signaling in COPD.
Junjuan Lu, Caihong Liu, Ting Yuan, Honghui Yang, Li Zhang
Published: 202510.1016/j.trsl.2025.12.004
Abstract
BACKGROUND: Chronic obstructive pulmonary disease (COPD) is a chronic respiratory condition primarily caused by inhalation of harmful particles such as tobacco smoke. Cellular senescence serves as a key driver in its pathogenesis. Although endothelia…
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