Translational research : the journal of laboratory and clinical medicineCrohn DiseaseEpiregulinAnimalsHumansAdipocytes
Mesenteric adipocytes promote intestinal fibrosis and inflammation in Crohn's disease through epiregulin (EREG).
Yawei Zhang, Hengchang Yao, Kailing Xie, Hao Liu, Lichao Yang, Qiang Wu, Baojia Yao, Liangxin Peng, Zhixian Jiang, Qi Sun, Lianwen Yuan
Published: 202510.1016/j.trsl.2025.10.001
Abstract
BACKGROUND: The global incidence rate of Crohn's disease (CD) is rising, with mesenteric adipose tissue (MAT) playing a pivotal role in CD progression, particularly in fibrosis development. This study aimed to identify key genes in MAT that contribut…
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