Transplant immunologyRituximabHumansGraft RejectionTransplantationHeterologous
Rituximab-based antibody mediated rejection therapy modestly reduces Xenoreactive antibodies: Implications for pig-to-human xenotransplantation.
Szu-Tsen Yeh, Nicole A Marshall, Brent P Lehman, C Dustin Rubinstein, Dhanansayan Shanmuganayagam, Jennifer J Meudt, Robert R Redfield, Luis G Hidalgo, Tanja Dominko, David D Aufhauser
Published: 202610.1016/j.trim.2025.102343
Abstract
BACKGROUND: Anti-pig antibodies, including those targeting porcine glycans and swine leukocyte antigens, present a significant challenge to pig-to-human xenotransplantation. Current strategies for managing these antibodies are limited. We examine the…
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