Transfusion and apheresis science : official journal of the World Apheresis Association : official journal of the European Society for HaemapheresisHumansLeukapheresisSodium CitrateFemaleMale
Novel leukocytapheresis method using highly concentrated sodium citrate solution for the manufacturing of tisagenlecleucel.
Wataru Kitamura, Keiko Fujii, Masaya Abe, Kazuhiro Ikeuchi, Kana Washio, Fumio Otsuka, Yoshinobu Maeda, Nobuharu Fujii
Published: 202510.1016/j.transci.2025.104265
Abstract
For the manufacturing of tisagenlecleucel (tisa-cel) requires the non-mobilized mononuclear cell collection (MNC). CD3+ cell collection is performed using the same protocol as autologous peripheral blood stem cell harvest (auto-PBSCH), but this proce…
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