Translational oncology
Ferroptosis induction enhances anti-PD-1 efficacy in NSCLC via HIF-1α/PD-L1 modulation.
Zimin Wang, Hao Liu, Jiawei Liang, Ying Zhang, William C Cho, Minhua Ye, Dehua Ma, Min Kong, Chengchu Zhu, Jianfei Shen
Published: 202610.1016/j.tranon.2026.102685
Abstract
BACKGROUND: The monotherapeutic efficacy of immune checkpoint inhibitors (ICIs) remains unsatisfactory in patients suffering from non-small-cell lung cancer (NSCLC). Ferroptosis, an iron-dependent cell death process, has been identified as a promisin…
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