Toxicology letters
Busulfan plus cyclophosphamide induced spermatogenic dysfunction and recovery: A dynamic change perspective.
Tianyu Li, Zhichen Tang, Yaping Song, Min Su, Xiao Liu, Fuping Li, Xing Wei, Xiaolei Luo, Bin Zhou, Yanyun Wang, Lin Zhang
Published: 202610.1016/j.toxlet.2026.111833
Abstract
Busulfan combined with cyclophosphamide (BuCy) is a common conditioning regimen before hematopoietic stem cell transplantation, but it causes severe gonadotoxicity, with nearly half of male patients suffering from irreversible infertility. Existing m…
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