Toxicology letters
Piecing together the puzzles: Aryl hydrocarbon receptor-mediated genetic and epigenetic signatures in dioxin-induced carcinogenicity- A systematic review and meta-analysis.
Hefnawy Ahmad A, Siam Mohamed, Mofarih Y Alkhaldi, Hassan A Asiri, Atheer M Ali, Faisal A Shaher, Mubarak Sultan Al-Shahrani, Mohammed Ahmed Al-Qarni, Hossam M El-Hawary
Published: 202610.1016/j.toxlet.2026.111827
Abstract
BACKGROUND: Dioxins, are highly potent environmental carcinogens. Their toxic effects are mediated primarily by the Aryl Hydrocarbon Receptor (AhR). A comprehensive understanding of how AhR-induced genetic and epigenetic alterations drive carcinogene…
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