Toxicology lettersHumansTrichloroethyleneTrophoblastsCysteineCell Line

Exposure to the trichloroethylene metabolite S-(1,2-dichlorovinyl)-L-cysteine under hypoxic conditions (%O2 =2 %) alters differential gene expression and mitigates decreased invasion capacity, compared to normoxic conditions (%O2 ≥ 21 %) in HTR-8/SVneo cells.

Franny H Stein, Nora H Le, Elana R Elkin

Published: 202510.1016/j.toxlet.2025.111773

Abstract

Trichloroethylene (TCE) is a volatile organic compound used as an industrial solvent until the recent EPA phaseout. Despite regulatory restrictions, legacy TCE pollution persists in soil and groundwater and poses a risk to human health. This chemical…

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Exposure to the trichloroethylene metabolite S-(1,2-dichlorovinyl)-L-cysteine under hypoxic conditions (%O2 =2 %) alters differential gene expression and mitigates decreased invasion capacity, compared to normoxic conditions (%O2 ≥ 21 %) in HTR-8/SVneo cells.

Abstract

Exposure to the trichloroethylene metabolite S-(1,2-dichlorovinyl)-L-cysteine under hypoxic conditions (%O2 =2 %) alters differential gene expression and mitigates decreased invasion capacity, compared to normoxic conditions (%O2 ≥ 21 %) in HTR-8/SVneo cells.