Toxicology lettersAnimalsNLR FamilyPyrin Domain-Containing 3 ProteinRatsSprague-Dawley
Geniposide induces hepatotoxicity via the bile acid-induced activation of NLRP3 inflammasome and regulation of the FXR/PERK/TXNIP pathway.
Zhinan Jin, Shenghui Cheng, Baoyue Liu, Yixuan Liu, Yanming Wei, Xuliang Hao, Huifang Li
Published: 202510.1016/j.toxlet.2025.111740
Abstract
Gardenia jasminoides, as a widely used traditional Chinese medicine, excessive consumption of it may lead to severe liver injury. As the main hepatotoxic component in Gardenia jasminoides, the specific mechanism by which geniposide (GE) causes liver…
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