Toxicon : official journal of the International Society on Toxinology
Retrorsine-Induced Hepatotoxicity is Mediated by Inhibition of the EGFR/AKT/c-Jun Axis and Disruption of Calcium Homeostasis in Primary Hepatocytes.
Congcheng Zhang, Qin Zhang, Pan Wang, Hai Yin, Yiling Liu, Shuhang Zhang, Hao Lu
Published: 202610.1016/j.toxicon.2026.108998
Abstract
Pyrrolizidine alkaloids (PAs) occur in approximately 3%-5% of flowering plants and are common natural toxins; retrorsine is among the most hepatotoxic. Ingestion of PA-containing products is a major cause of hepatic sinusoidal obstruction syndrome (H…
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