Toxicology
Evaluating the absence of allometric scaling for hepatic microsomal Phase I and Phase II xenobiotic biotransformation among mammals.
Luke Ockhuijsen, Ad M J Ragas, A Jan Hendriks
Published: 202510.1016/j.tox.2025.154377
Abstract
Elucidating consistent patterns for xenobiotic biotransformation among mammals is challenging because of intrinsic species differences. At the organism level, pharmacokinetic rate constants are believed to scale allometrically to body weight with a p…
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