Titanium nanoparticles provoke ferritinophagy-mediated ferroptosis via inhibition of the Nrf2-HO-1 signaling pathway in osteocytes.

Wear particles-induced osteolysis is the primary cause of aseptic loosening and subsequent joint replacement failure. Osteocytes, the most abundant cells in bone, are in direct contact with implants; however, the interaction between osteocytes and we…

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