The journal of prevention of Alzheimer's disease
Synaptic toxicity of OGA inhibitors and the failure of ceperognastat.
Jonathan Meade, Haylee Mesa, Shahriar Alamgir, Isabell Bieniecka, Lei Liu, Qi Zhang
Published: 202610.1016/j.tjpad.2025.100456
Abstract
O-GlcNAcase inhibitors (OGAi) have emerged as a promising therapeutic strategy in Alzheimer's disease (AD) by enhancing O-GlcNAcylation, which competes with tau phosphorylation and reduces tau aggregation. However, the Phase II clinical trial failure…
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