The Journal of nutrition
Leucine Alleviates Endoplasmic Reticulum-Stress Mediated Lipotoxic Injury Induced by High-Fat Diet Via Sar1b/Sestrin2/Ampkα1 Pathways in Acanthopagrus Schlegelii.
Wenli Zhao, Yuedong Shen, Xuan Wang, Yangguang Bao, Óscar Monroig, Tingting Zhu, Xie Shichao, Peng Sun, Douglas R Tocher, Qicun Zhou, Min Jin
Published: 202510.1016/j.tjnut.2025.101258
Abstract
BACKGROUND: With the increasing use of high-fat diet (HFD), fatty liver has become prevalent in farmed fish. Leucine regulates lipid metabolism via multiple pathways, but its role in hepatic lipotoxic injury remains unclear. OBJECTIVE: This study aim…
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