Toxicology in vitro : an international journal published in association with BIBRAAnimalsAtrazineFemaleRatsSprague-Dawley
Quantitative in vitro to in vivo extrapolation (QIVIVE) of atrazine's effects on phosphodiesterase and aromatase mRNA expression in vitro to the rat in vivo based on pharmacokinetic.
James W Simpkins, Ralph L Cooper, Charles Breckenridge
Published: 202610.1016/j.tiv.2025.106177
Abstract
This study investigated the effects of atrazine (ATZ) and its metabolites on phosphodiesterase (PDE) activity ex vivo and aromatase mRNA expression in two steroidogenic cell lines (H295R and JEG-3). The pharmacokinetics of ATZ and its chlorometabolit…
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