Trends in pharmacological sciencesHumansArmadillo Domain ProteinsAnimalsCytoskeletal ProteinsNeuroprotective Agents
Targeting SARM1: from inhibition for neuroprotection to activation for neuroablation.
Peter Arthur-Farraj, Andrea Loreto
Published: 202510.1016/j.tips.2025.09.003
Abstract
Sterile alpha and TIR motif-containing protein 1 (SARM1),is a central enzyme that drives programmed axon degeneration and has gathered significant interest as a therapeutic target. Despite preclinical development of inhibitory therapeutic approaches,…
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