Trends in pharmacological sciencesHumansAnimalsUbiquitinationUbiquitin-Protein LigasesSmall Ubiquitin-Related Modifier Proteins
Reprogramming SUMO-primed ubiquitylation: opportunities in oncology and neurology.
Gina Gotthardt, Jan Keiten-Schmitz, Stefan Müller
Published: 202510.1016/j.tips.2025.09.002
Abstract
Drugs that reprogram the cellular ubiquitin-proteasome system for removal of disease-causing proteins hold great promise as a new type of pharmacology. Small ubiquitin-related modifier (SUMO)-targeted ubiquitin ligases (StUbLs) are E3 ubiquitin ligas…
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