Trends in microbiology
Cellular and viral RNA polymerases: evolutionary insights into eukaryotic origins.
Kuan Yee Wong, Xiaoyuan Feng, Xiaojun Wang, Xiong Ji, Zhichao Zhou
Published: 202510.1016/j.tim.2025.11.008
Abstract
Nucleocytoplasmic large DNA viruses (NCLDVs) encode multi-subunit RNA polymerases (msRNAPs) that challenge conventional views of viral evolution. Phylogenetic and structural studies reveal that NCLDV RNAP catalytic cores share deep evolutionary roots…
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