Trends in genetics : TIG
Lysosomal activation leaves a lasting memory.
Amaresh Chaturbedi, Charles Lowell Heinke, Siu Sylvia Lee
Published: 202510.1016/j.tig.2025.11.005
Abstract
Beyond their degradative role, lysosomes help prepare Caenorhabditis elegans offspring for stress. In a recent study, Zhang et al. show that lysosomal activation induces somatic histone H3.3 production, which moves to the germline and is methylated a…
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