Tissue & cell
Brexpiprazole induces acute cardiotoxicity via disrupting calcineurin/NFAT and calcium signaling pathway: A validation from biochemical, echocardiographic, histological, and computational analysis.
Mohammed Alissa, Suad A Alghamdi, Abdulkarim S Binshaya, Tawfiq N Juraybi, Awaji Y Safhi, Amal A Albati, Adil Abalkhail, Adel M Alqarni
Published: 202610.1016/j.tice.2026.103340
Abstract
Brexpiprazole (BPZ) is a third-generation atypical antipsychotic drug that is reported to induce various organ toxicity in non-target organisms. The current investigation was conducted to explore the dose-dependent toxicity of BPZ on cardiac tissues.…
Preview only. Read the full abstract at the source