Tissue & cell
Smad7 drives cisplatin resistance in ovarian cancer via a PRMT5-dependent mechanism.
Jinlong Ji, Kexin Wang, Geshuyi Chen, Manman Zhao, Cong Wan, Yun Han, Yanli Zheng
Published: 202510.1016/j.tice.2025.103304
Abstract
Acquired cisplatin resistance poses a major challenge in ovarian cancer management. This study investigated the role of protein arginine methyltransferase 5 (PRMT5) in this context. Using cisplatin-resistant ovarian cancer cell lines (A2780/DDP and S…
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