Tissue & cell
Pumpkin seed oil improves hepatotoxicity in rats through inhibition of CYP2E1 and activation of Nrf2 signaling pathways.
Noran W Esmail, Sawsan M El-Sheikh, Reda M S Korany, Arwa A Hassan, Sara M Baraka, Hanan M Alharbi, Ayman K Ismail, Doaa A Mansour, Heba H Mahboub, Esraa M Fahmy
Published: 202510.1016/j.tice.2025.103286
Abstract
Pumpkin seed oil (PSO) possesses multiple pharmacological properties, including antioxidant, anti-inflammatory, and anti-apoptotic effects. Given that paracetamol (PCM) is a common cause of drug-induced hepatic injury, the present study aimed to eval…
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