Tissue & cell
A practical workflow for fixation and autofluorescence reduction in correlative light and electron microscopy of postmortem human brain tissue.
Ha-Eon Lee, Hong Lim Kim, Ara Cho, Do-Gyun Kim, Min-Jin Park, Yuna Oh, Yong Soo Park, Rafael T Han, Mun-Yong Lee, Tae-Ryong Riew
Published: 202510.1016/j.tice.2025.103284
Abstract
BACKGROUND: Correlative Light and Electron Microscopy (CLEM) on postmortem human brain tissue is limited by poor ultrastructural preservation and high endogenous autofluorescence. Furthermore, many existing protocols lack the flexibility required for…
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