Trends in biotechnology
Precision tumor immunotherapy via a dual-gated macrophage-bacterial activation platform.
Lin Li, Leyang Wu, Liyuan Qiao, Shuhui Zhang, Xiaowei Luan, Jiahui Qiu, Xinyue Qiao, Chenyang Li, Ying Sun, Bohao Wang, Zengzheng Du, Xiaoyao Chang, Hongqin Zhuang, Tao Zhang, Yanlong Jia
Published: 202510.1016/j.tibtech.2025.09.013
Abstract
Immunotherapy based on live microorganisms has shown promise in preclinical studies, but its clinical translation has been hampered by limited efficacy and non-negligible toxicity. Here, we developed Macrophage-Bacteria encapsulation Lytic Autoactiva…
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