Trends in biochemical sciences
DNA binding is a defining feature of BRCA2 orthologs.
Alice Chanteau, Fabien Nogué, Rajeev Kumar
Published: 202610.1016/j.tibs.2025.12.010
Abstract
BReast CAncer 2 (BRCA2) safeguards genome integrity across eukaryotes by facilitating DNA repair. A defining feature of BRCA2 orthologs is their ability to bind to DNA. Here, we highlight emerging roles of multiple DNA-binding modules that act in a c…
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